LOEWE Center for
Insect Biotechnology
& Bioresources

Karina Brinkrolf

Dr. rer. nat.

Research Associante

Phone: +49 641 99-35807

Email: karina.brinkrolf@bio.uni-giessen.de

Room: 0151

Building: HBR58


since 2020

Scientific associate at AG Bioinformatics and Systems Biology, Justus Liebig University Giessen

2017 - 2020

Group leader “Microbial Genomics” at Fraunhofer IME-BR, Gießen

2015 - 2016

Postdoc at Fraunhofer IME-BR, Gießen

2010 - 2015

Postdoc at Center for Biotechnology, Bielefeld University

2011 - 2012

Coordination of CLIB-Graduate Cluster Industrial Biotechnology at Center for Biotechnology, Bielefeld University

2008 - 2010

Postdoc at Center for Biotechnology, Bielefeld University

2005 - 2008

PhD student at the chair of genetics, Bielefeld University

2003 - 2004

Diploma student at the chair of genetics, Bielefeld University

1998 - 2004

Studies in biology, Bielefeld University


Rupp O, MacDonald ML, Li S, Dhiman H, Polson S, Griep S, Heffner K, Hernandez I, Brinkrolf K, Jadhav V, Samoudi M, Hao H, Kingham B, Goesmann A, Betenbaugh MJ, Lewis NE, Borth N, Lee KH (2018) A reference genome of the Chinese hamster based on a hybrid assembly strategy. Biotechnology and Bioengineering,
Wippermann A, Rupp O, Brinkrolf K, Hoffrogge R, Noll T (2017) Integrative analysis of DNA methylation and gene expression in butyrate-treated CHO cells. Journal of Biotechnology, 257 , 150-161.
Merten M, Brinkrolf K, Albersmeier A, Kutter Y, Rückert C, Tauch A (2015) Complete Genome Sequence and Annotation of Corynebacterium singulare DSM 44357, Isolated from a Human Semen Specimen. Genome Announcements, 3 (2) , 1–2.
Rupp O, Brinkrolf K, Buerth C, Kunigo M, Schneider J, Jaenicke S, Goesmann A, Pühler A, Jaeger KE, Ernst JF (2015) The structure of the Cyberlindnera jadinii genome and its relation to Candida utilis analyzed by the occurrence of single nucleotide polymorphisms. Journal of Biotechnology, 211 , 20–30.
Wippermann A, Rupp O, Brinkrolf K, Hoffrogge R, Noll T (2015) The DNA methylation landscape of Chinese hamster ovary (CHO) DP-12 cells. Journal of Biotechnology, 199 , 38–46.
Becker J, Timmermann C, Rupp O, Albaum SP, Brinkrolf K, Goesmann A, Pühler A, Tauch A, Noll T (2014) Transcriptome analyses of CHO cells with the next-generation microarray CHO41K: Development and validation by analysing the influence of the growth stimulating substance IGF-1 substitute LongR3 Journal of Biotechnology, 178 , 23–31.
Brinkrolf K, Hoffrogge R, Hackl M, Tauch A, Baumann M, Noll T, Goesmann A, Pühler A, Borth N (2014) Functional -Omics for Cell Lines and Processes: The -Omics Technologies on the Example of CHO Cells , in Animal Cell Biotechnology. In Biologics Production., Hauser H, Wagner R (Eds.) , 326–367. De Gruyter: Berlin, Boston
Glaub A, Bomholt C, Gravermann K, Brinkrolf K, Albersmeier A, Rückert C, Tauch A (2014) Complete Genome Sequence of Corynebacterium falsenii DSM 44353 To Study the Evolution of Corynebacterium Cluster 3 Species Genome Announcements, 2 (2) , 1–2.
Jakobi T, Brinkrolf K, Tauch A, Noll T, Stoye J, Pühler A, Goesmann A (2014) Discovery of transcription start sites in the Chinese hamster genome by next-generation RNA sequencing. Journal of Biotechnology, 190 , 64–75.
Rupp O, Becker J, Brinkrolf K, Timmermann C, Borth N, Pühler A, Noll T, Goesmann A (2014) Construction of a public CHO cell line transcript database using versatile bioinformatics analysis pipelines. PLoS ONE, 9 (1) , 1–13.
Tippelt A, Albersmeier A, Brinkrolf K, Rückert C, Fernández-Natal I, Soriano F, Tauch A (2014) Complete Genome Sequence of Corynebacterium ureicelerivorans DSM 45051, a Lipophilic and Urea-Splitting Isolate from the Blood Culture of a Septicemia Patient. Genome Announcements, 2 (6) , 1–2.
Bomholt C, Glaub A, Gravermann K, Albersmeier A, Brinkrolf K, Rückert C, Tauch A (2013) Whole-Genome Sequence of the Clinical Strain Corynebacterium argentoratense DSM 44202, Isolated from a Human Throat Specimen. 1, 5 , 1–2.
Brinkrolf K, Rupp O, Laux H, Kollin F, Ernst W, Linke B, Kofler R, Romand S, Hesse F, Budach WE, Galosy S, Müller D, Noll T, Wienberg J, Jostock T, Leonard M, Grillari J, Tauch A, Goesmann A, Helk B, Mott JE, Pühler A, Borth N (2013) Chinese hamster genome sequenced from sorted chromosomes. Nature Biotechnology, 31 (8) , 694–695.
Brinkrolf K, Schneider J, Knecht M, Rückert C, Tauch A (2012) Draft genome sequence of Turicella otitidis ATCC 51513, isolated from middle ear fluid from a child with otitis media. Journal of Bacteriology, 194 (21) , 5968–5969.
Hackl M, Jadhav V, Jakobi T, Rupp O, Brinkrolf K, Goesmann A, Pühler A, Noll T, Borth N, Grillari J (2012) Computational identification of microRNA gene loci and precursor microRNA sequences in CHO cell lines. Journal of Biotechnology, 158 (3) , 151–155.
Meleady P, Hoffrogge R, Henry M, Rupp O, Bort JH, Clarke C, Brinkrolf K, Kelly S, Müller B, Doolan P, Hackl M, Beckmann TF, Noll T, Grillari J, Barron N, Pühler A, Clynes M, Borth N (2012) Utilization and evaluation of CHO-specific sequence databases for mass spectrometry based proteomics. Biotechnology and Bioengineering, 109 (6) , 1386–1394.
Schneider J, Andrea H, Blom J, Jaenicke S, Rückert C, Schorsch C, Szczepanowski R, Farwick M, Goesmann A, Pühler A, Schaffer S, Tauch A, Köhler T, Brinkrolf K (2012) Draft genome sequence of Wickerhamomyces ciferrii NRRL Y-1031 F-60-10. Eukaryotic Cell, 11 (12) , 1582–1583.
Schneider J, Rupp O, Trost E, Jaenicke S, Passoth V, Goesmann A, Tauch A, Brinkrolf K (2012) Genome sequence of Wickerhamomyces anomalus DSM 6766 reveals genetic basis of biotechnologically important antimicrobial activities. FEMS Yeast Research, 12 (3) , 382–386.
Becker J, Hackl M, Rupp O, Jakobi T, Schneider J, Szczepanowski R, Bekel T, Borth N, Goesmann A, Grillari J, Kaltschmidt C, Noll T, Pühler A, Tauch A, Brinkrolf K (2011) Unraveling the Chinese hamster ovary cell line transcriptome by next-generation sequencing. Journal of Biotechnology, 156 (3) , 227–235.
Becker J, Timmermann C, Jakobi T, Rupp O, Szczepanowski R, Hackl M, Goesmann A, Tauch A, Borth N, Grillari J, Pühler A, Noll T, Brinkrolf K (2011) Next-generation sequencing of the CHO cell transcriptome. BMC Proceedings, 5 Suppl 8 (P6) , 1–2.
Hackl M, Jakobi T, Blom J, Doppmeier D, Brinkrolf K, Szczepanowski R, Bernhart SH, Höner Zu Siederdissen C, Bort JA, Wieser M, Kunert R, Jeffs S, Hofacker IL, Goesmann A, Pühler A, Borth N, Grillari J (2011) Next-generation sequencing of the Chinese hamster ovary microRNA transcriptome: Identification, annotation and profiling of microRNAs as targets for cellular engineering. Journal of Biotechnology, 153 (1–2) , 62–75.
Küberl A, Schneider J, Thallinger GG, Anderl I, Wibberg D, Hajek T, Jaenicke S, Brinkrolf K, Goesmann A, Szczepanowski R, Pühler A, Schwab H, Glieder A, Pichler H (2011) High-quality genome sequence of Pichia pastoris CBS7435 Journal of Biotechnology, 154 (2) , 312–320.
Schneider J, Blom J, Jaenicke S, Linke B, Brinkrolf K, Neuweger H, Tauch A, Goesmann A (2011) RAPYD — Rapid Annotation Platform for Yeast Data Journal of Biotechnology, 155 (1) , 118–126.
Brinkrolf K, Schröder J, Pühler A, Tauch A (2010) The transcriptional regulatory repertoire of Corynebacterium glutamicum: reconstruction of the network controlling pathways involved in lysine and glutamate production. Journal of Biotechnology, 149 (3) , 173–182.
Jochmann N, Kurze AK, Czaja LF, Brinkrolf K, Brune I, Hüser AT, Hansmeier N, Pühler A, Borovok I, Tauch A (2009) Genetic makeup of the Corynebacterium glutamicum LexA regulon deduced from comparative transcriptomics and in vitro DNA band shift assays. Microbiology, 155 (Pt 5) , 1459–1477.
Nentwich SS, Brinkrolf K, Gaigalat L, Hüser AT, Rey DA, Mohrbach T, Marin K, Pühler A, Tauch A, Kalinowski J (2009) Characterization of the LacI-type transcriptional repressor RbsR controlling ribose transport in Corynebacterium glutamicum ATCC 13032 Microbiology, 155 (Pt 1) , 150–164.
Brinkrolf K, Plöger S, Solle S, Brune I, Nentwich SS, Hüser AT, Kalinowski J, Pühler A, Tauch A (2008) The LacI/GalR family transcriptional regulator UriR negatively controls uridine utilization of Corynebacterium glutamicum by binding to catabolite-responsive element ()-like sequences. Microbiology, 154 (Pt 4) , 1068–1081.
Tauch A, Schneider J, Szczepanowski R, Tilker A, Viehoever P, Gartemann KH, Arnold W, Blom J, Brinkrolf K, Brune I, Götker S, Weisshaar B, Goesmann A, Dröge M, Pühler A (2008) Ultrafast pyrosequencing of Corynebacterium kroppenstedtii DSM44385 revealed insights into the physiology of a lipophilic corynebacterium that lacks mycolic acids. Journal of Biotechnology, 136 (1–2) , 22–30.
Tauch A, Trost E, Tilker A, Ludewig U, Schneiker S, Goesmann A, Arnold W, Bekel T, Brinkrolf K, Brune I, Götker S, Kalinowski J, Kamp PB, Lobo FP, Viehoever P, Weisshaar B, Soriano F, Dröge M, Pühler A (2008) The lifestyle of Corynebacterium urealyticum derived from its complete genome sequence established by pyrosequencing. Journal of Biotechnology, 136 (1–2) , 11–21.
Baumbach J, Wittkop T, Rademacher K, Rahmann S, Brinkrolf K, Tauch A (2007) CoryneRegNet 3.0—an interactive systems biology platform for the analysis of gene regulatory networks in corynebacteria and Escherichia coli. Journal of Biotechnology, 129 (2) , 279–289.
Brinkrolf K, Brune I, Tauch A (2007) The transcriptional regulatory network of the amino acid producer Corynebacterium glutamicum. Journal of Biotechnology, 129 (2) , 191–211.
Brune I, Jochmann N, Brinkrolf K, Hüser AT, Gerstmeir R, Eikmanns BJ, Kalinowski J, Pühler A, Tauch A (2007) The IclR-type transcriptional repressor LtbR regulates the expression of leucine and tryptophan biosynthesis genes in the amino acid producer Corynebacterium glutamicum. Journal of Bacteriology, 189 (7) , 2720–2733.
Baumbach J, Brinkrolf K, Czaja LF, Rahmann S, Tauch A (2006) CoryneRegNet: an ontology-based data warehouse of corynebacterial transcription factors and regulatory networks. BMC Genomics, 7 (24) , 1–12.
Baumbach J, Brinkrolf K, Wittkop T, Tauch A, Rahmann S (2006) CoryneRegNet 2: An integrative bioinformatics approach for reconstruction and comparison of transcriptional regulatory networks in prokaryotes. Journal of Integrative Bioinformatics, 3 (2) , 24.
Brinkrolf K, Brune I, Tauch A (2006) Transcriptional regulation of catabolic pathways for aromatic compounds in Corynebacterium glutamicum. Genetics and Molecular Research, 5 (4) , 773–789.
Brune I, Brinkrolf K, Kalinowski J, Pühler A, Tauch A (2005) The individual and common repertoire of DNA-binding transcriptional regulators of Corynebacterium glutamicum, Corynebacterium efficiens, Corynebacterium diphtheriae and Corynebacterium jeikeium deduced from the complete gen... BMC Genomics, 6 (86) , 1–10.